Migraine is a chronic neurovascular disorder occurring in both genders, although large surveys show higher prevalence of this condition in women, with a female to male ratio in the order of 3:1. (1) Although migraine acknowledges a complex pathophysiology, involving genetic and psychological factors, the disproportionate number of fertile women with migraine suggests that hormonal factors may indeed play an important role in the pathogenesis of migraine. (1) In addition, attacks are usually reported to be more severe and difficult to treat in women than in men. (1)

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  1. Franconi F. et al.; Neurol Sci 2014; 35(Suppl. 1): S99-S105
To whom it may concern: please note that all adverse events occurring with the treatment of migraine with frovatriptan should be reported. Please refer to your local policies and rules for proper adverse events reporting to the relevant local healthcare authorities.